2-Nitro-1-vinyl-1H-imidazole

Nitroimidazoles are pharmacophoric groups responsible for important antiparasitic activity against several infectious diseases. 2-Nitroimidazoles found in some drugs and one of the main moieties biological activities exhibited. As an example, we can mention drug benznidazole, only available Brazil treatment Chagas disease. This work describes efficient methodology synthesis 2-nitro-1-vinyl-1H-imidazole through a simple direct approach, as well its full characterization assessment. The evaluation Trypanosoma cruzi (Tulahuen C2C4-LacZ strain) showed IC50 = 4.8 μM on amastigotes low cytotoxicity LLC-MK2 cells (IC50 > 500 μM), validating biologically active structural subunit anti-T. activity. results presented herein demonstrate that be easily obtained, possessing great potential use design new antichagasic molecular hybridization strategy using known coupling reactions.